Workshop Transcriptional memory in health and disease
Presentación y objetivos
The idea that cells remember past states to prepare their future endeavors has split into two parallel languages that rarely converse. On one side, chromatin epigenetics defines inheritance through the material continuity of molecular marks such as chromatin modifications, which can be faithfully propagated through replication and mitosis. On the other, regulatory network epigenetics views memory as an emergent property of circuit dynamics such as feedback loops, attractor states, and gene modules that retain information across cell generations. Each framework has achieved remarkable depth and explanatory power, profoundly shaping our understanding of development, homeostasis and disease. Yet, their integration remains incomplete.
This workshop seeks to collapse these views into a unified perspective by placing chromatin inheritance and network memory in direct dialogue, from chromatin states to gene circuits: we aim at building a shared understanding of transcriptional memory as a multi-layered, dynamically encoded system of inheritance. Only by merging and integrating molecular and systems perspectives in molecular, physical and mathematical frameworks, can we fully explain how stability and flexibility coexist in living systems, how these principles are subverted in disease, and how they might be harnessed for therapeutic innovation.
Together, we will replace parallel monologues with a true dialogue between chromatin inheritance and regulatory network memory, laying the foundations for a predictive and reprogrammable understanding of cellular identity.
Instituciones participantes
